A robust method for designing multistable systems by embedding bistable subsystems

主讲人：田天海 澳大利亚莫纳什大学教授

时间：2022年12月16日15：00

地点：腾讯会议 838 660 000

举办单位：数理学院

内容介绍：In this talk we discuss a robust method to develop multistable mathematical models by embedding bistable models together. Using the GATA1-GATA2-PU.1 module in hematopoiesis as the test system, we discuss a tristable model based on two bistable models without any high cooperative coefficients, and then modify the tristable model based on experimentally determined mechanisms. The modified model successfully realises four stable steady states and accurately reflects a recent experimental observation showing four transcriptional states. The proposed method is a general approach to develop mathematical models for realising multistability and heterogeneity in complex systems.